Asian Journal of Sports Medicine

Published by: Kowsar

Effects of L-Carnitine Supplementation on Metabolic Utilization of Oxygen and Lipid Profile among Trained and Untrained Humans

Jirakrit Leelarungrayub 1 , * , Decha Pinkaew 1 , Jakkrit Klaphajone 2 , Wichai Eungpinichpong 3 and Richard J. Bloomer 4
Authors Information
1 Department of Physical Therapy, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai 50200, Thailand
2 Department of Rehabilitation Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand
3 Research Center in Back, Neck, Other Joint Pain and Human Performance, Khon Kaen University, Khon Kaen 40002, Thailand
4 Cardiorespiratory/Metabolic Laboratory, School of Health Studies, University of Memphis, Memphis TN 38152, USA
Article information
  • Asian Journal of Sports Medicine: March 2017, 8 (1); e38707
  • Published Online: December 27, 2016
  • Article Type: Research Article
  • Received: April 25, 2016
  • Revised: November 18, 2016
  • Accepted: January 1, 1970
  • DOI: 10.5812/asjsm.38707

To Cite: Leelarungrayub J, Pinkaew D, Klaphajone J, Eungpinichpong W, Bloomer R J. Effects of L-Carnitine Supplementation on Metabolic Utilization of Oxygen and Lipid Profile among Trained and Untrained Humans, Asian J Sports Med. 2017 ; 8(1):e38707. doi: 10.5812/asjsm.38707.

Abstract
Copyright © 2016, Sports Medicine Research Center. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Methods
3. Results
4. Discussion
5. Conclusions and Limitation
Footnotes
References
  • 1. Bloomer RJ, Farney TM, McAllister MJ. Nutrition and Enhanced Sports Performance, Chapter 41. 2013; : 405-13
  • 2. Gramignano G, Lusso MR, Madeddu C, Massa E, Serpe R, Deiana L, et al. Efficacy of l-carnitine administration on fatigue, nutritional status, oxidative stress, and related quality of life in 12 advanced cancer patients undergoing anticancer therapy. Nutrition. 2006; 22(2): 136-45[DOI][PubMed]
  • 3. Malaguarnera M, Gargante MP, Cristaldi E, Colonna V, Messano M, Koverech A, et al. Acetyl L-carnitine (ALC) treatment in elderly patients with fatigue. Arch Gerontol Geriatr. 2008; 46(2): 181-90[DOI][PubMed]
  • 4. Ribas GS, Vargas CR, Wajner M. L-carnitine supplementation as a potential antioxidant therapy for inherited neurometabolic disorders. Gene. 2014; 533(2): 469-76[DOI][PubMed]
  • 5. Mescka CP, Guerreiro G, Hammerschmidt T, Faverzani J, de Moura Coelho D, Mandredini V, et al. L-Carnitine supplementation decreases DNA damage in treated MSUD patients. Mutat Res. 2015; 775: 43-7[DOI][PubMed]
  • 6. Delaney CL, Spark JI, Thomas J, Wong YT, Chan LT, Miller MD. A systematic review to evaluate the effectiveness of carnitine supplementation in improving walking performance among individuals with intermittent claudication. Atherosclerosis. 2013; 229(1): 1-9[DOI][PubMed]
  • 7. Johri AM, Heyland DK, Hetu MF, Crawford B, Spence JD. Carnitine therapy for the treatment of metabolic syndrome and cardiovascular disease: evidence and controversies. Nutr Metab Cardiovasc Dis. 2014; 24(8): 808-14[DOI][PubMed]
  • 8. Bacurau RF, Navarro F, Bassit RA, Meneguello MO, Santos RV, Almeida AL, et al. Does exercise training interfere with the effects of L-carnitine supplementation? Nutrition. 2003; 19(4): 337-41[PubMed]
  • 9. Gulcin I. Antioxidant and antiradical activities of L-carnitine. Life Sci. 2006; 78(8): 803-11[DOI][PubMed]
  • 10. Sahlin K, Sallstedt EK, Bishop D, Tonkonogi M. Turning down lipid oxidation during heavy exercise--what is the mechanism? J Physiol Pharmacol. 2008; 59 Suppl 7: 19-30[PubMed]
  • 11. Brass EP, Hiatt WR. Carnitine metabolism during exercise. Life Sci. 1994; 54(19): 1383-93[PubMed]
  • 12. Constantin-Teodosiu D, Carlin JI, Cederblad G, Harris RC, Hultman E. Acetyl group accumulation and pyruvate dehydrogenase activity in human muscle during incremental exercise. Acta Physiol Scand. 1991; 143(4): 367-72[DOI][PubMed]
  • 13. Karlic H, Lohninger A. Supplementation of L-carnitine in athletes: does it make sense? Nutrition. 2004; 20(7-8): 709-15[DOI][PubMed]
  • 14. Stanley WC, Recchia FA, Lopaschuk GD. Myocardial substrate metabolism in the normal and failing heart. Physiol Rev. 2005; 85(3): 1093-129[DOI][PubMed]
  • 15. Broderick TL, Quinney HA, Lopaschuk GD. Carnitine stimulation of glucose oxidation in the fatty acid perfused isolated working rat heart. J Biol Chem. 1992; 267(6): 3758-63[PubMed]
  • 16. Saddik M, Gamble J, Witters LA, Lopaschuk GD. Acetyl-CoA carboxylase regulation of fatty acid oxidation in the heart. J Biol Chem. 1993; 268(34): 25836-45[PubMed]
  • 17. Kolodziejczyk J, Saluk-Juszczak J, Wachowicz B. L-Carnitine protects plasma components against oxidative alterations. Nutrition. 2011; 27(6): 693-9[DOI][PubMed]
  • 18. Arduini A, Bonomini M, Savica V, Amato A, Zammit V. Carnitine in metabolic disease: potential for pharmacological intervention. Pharmacol Ther. 2008; 120(2): 149-56[DOI][PubMed]
  • 19. Lee BJ, Lin JS, Lin YC, Lin PT. Antiinflammatory effects of L-carnitine supplementation (1000 mg/d) in coronary artery disease patients. Nutrition. 2015; 31(3): 475-9[DOI][PubMed]
  • 20. Alesci S, De Martino MU, Mirani M, Benvenga S, Trimarchi F, Kino T, et al. L-carnitine: A nutritional modulator of glucocorticoid receptor functions. FASEB J. 2003; 17(11): 1553-5[DOI][PubMed]
  • 21. Schmengler U, Ungru J, Boston R, Coenen M, Vervuert I. Effects of l-carnitine supplementation on body weight losses and metabolic profile in obese and insulin-resistant ponies during a 14-week body weight reduction programme. Livestock Science. 2013; 155(2-3): 301-7[DOI]
  • 22. Coleman RA, Lee DP. Enzymes of triacylglycerol synthesis and their regulation. Prog Lipid Res. 2004; 43(2): 134-76[PubMed]
  • 23. Muller DM, Seim H, Kiess W, Loster H, Richter T. Effects of oral L-carnitine supplementation on in vivo long-chain fatty acid oxidation in healthy adults. Metabolism. 2002; 51(11): 1389-91[PubMed]
  • 24. Greig C, Finch KM, Jones DA, Cooper M, Sargeant AJ, Forte CA. The effect of oral supplementation with L-carnitine on maximum and submaximum exercise capacity. Eur J Appl Physiol Occup Physiol. 1987; 56(4): 457-60[PubMed]
  • 25. Wyss V, Ganzit GP, Rienzi A. Effects of L-carnitine administration on VO2max and the aerobic-anaerobic threshold in normoxia and acute hypoxia. Eur J Appl Physiol Occup Physiol. 1990; 60(1): 1-6[PubMed]
  • 26. Vecchiet L, Di Lisa F, Pieralisi G, Ripari P, Menabo R, Giamberardino MA, et al. Influence of L-carnitine administration on maximal physical exercise. Eur J Appl Physiol Occup Physiol. 1990; 61(5-6): 486-90[PubMed]
  • 27. Natali A, Santoro D, Brandi LS, Faraggiana D, Ciociaro D, Pecori N, et al. Effects of acute hypercarnitinemia during increased fatty substrate oxidation in man. Metabolism. 1993; 42(5): 594-600[PubMed]
  • 28. de Vreede PL, Samson MM, van Meeteren NL, van der Bom JG, Duursma SA, Verhaar HJ. Functional tasks exercise versus resistance exercise to improve daily function in older women: a feasibility study. Arch Phys Med Rehabil. 2004; 85(12): 1952-61[PubMed]
  • 29. ACSM's guidelines for exercise testing and prescription. 2010;
  • 30. ACSM's guidelines for exercise testing and prescription. 2004;
  • 31. Sharma P, Morris NR, Adams L. The effect of different exercise modalities on dyspnea and leg fatigue in healthy subjects. Respir Physiol Neurobiol. 2015; 210: 44-50[DOI][PubMed]
  • 32. Said M, Feki Y, Hamza M, Machghoul S, Amri M. Effects of two kinds of exhaustive maximal exercise on pro-inflammatory cytokines concentrations in trained and untrained humans. Biol Sport. 2005; 22(4): 329
  • 33. El Assar M, Angulo J, Rodriguez-Manas L. Oxidative stress and vascular inflammation in aging. Free Radic Biol Med. 2013; 65: 380-401[DOI][PubMed]
  • 34. Gianni P, Jan KJ, Douglas MJ, Stuart PM, Tarnopolsky MA. Oxidative stress and the mitochondrial theory of aging in human skeletal muscle. Exp Gerontol. 2004; 39(9): 1391-400[DOI][PubMed]
  • 35. Ho JY, Kraemer WJ, Volek JS, Fragala MS, Thomas GA, Dunn-Lewis C, et al. l-Carnitine l-tartrate supplementation favorably affects biochemical markers of recovery from physical exertion in middle-aged men and women. Metabolism. 2010; 59(8): 1190-9[DOI][PubMed]
  • 36. Belli T, Ribeiro LF, Ackermann MA, Baldissera V, Gobatto CA, Galdino da Silva R. Effects of 12-week overground walking training at ventilatory threshold velocity in type 2 diabetic women. Diabetes Res Clin Pract. 2011; 93(3): 337-43[DOI][PubMed]
  • 37. Beaver WL, Wasserman K, Whipp BJ. A new method for detecting anaerobic threshold by gas exchange. J Appl Physiol (1985). 1986; 60(6): 2020-7[PubMed]
  • 38. Bisi MC, Stagni R, Gnudi G. Automatic detection of maximal oxygen uptake and ventilatory threshold. Comput Biol Med. 2011; 41(1): 18-23[DOI][PubMed]
  • 39. Pereira MC, Rocha Junior Vde A, Bottaro M, de Andrade MM, Schwartz FP, Martorelli A, et al. Relationship between ventilatory threshold and muscle fiber conduction velocity responses in trained cyclists. J Electromyogr Kinesiol. 2013; 23(2): 448-54[DOI][PubMed]
  • 40. Egan B, Zierath JR. Exercise metabolism and the molecular regulation of skeletal muscle adaptation. Cell Metab. 2013; 17(2): 162-84[DOI][PubMed]
  • 41. Gielen S, Schuler G, Adams V. Cardiovascular effects of exercise training: molecular mechanisms. Circulation. 2010; 122(12): 1221-38[DOI][PubMed]
  • 42. Hawley JA, Brouns F, Jeukendrup A. Strategies to enhance fat utilisation during exercise. Sports Med. 1998; 25(4): 241-57[PubMed]
  • 43. Tunstall RJ, Mehan KA, Wadley GD, Collier GR, Bonen A, Hargreaves M, et al. Exercise training increases lipid metabolism gene expression in human skeletal muscle. Am J Physiol Endocrinol Metab. 2002; 283(1)-72[DOI][PubMed]
  • 44. Hathcock JN, Shao A. Risk assessment for carnitine. Regul Toxicol Pharmacol. 2006; 46(1): 23-8[DOI][PubMed]
  • 45. Steiber A, Kerner J, Hoppel CL. Carnitine: a nutritional, biosynthetic, and functional perspective. Mol Aspects Med. 2004; 25(5-6): 455-73[DOI][PubMed]
  • 46. Sullivan GM, Feinn R. Using Effect Size-or Why the P Value Is Not Enough. J Grad Med Educ. 2012; 4(3): 279-82[DOI][PubMed]
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