Asian Journal of Sports Medicine

Published by: Kowsar

Protective Role of Aerobic Exercise Against Cisplatin-Induced Nephrotoxicity in Rats

Farzaneh Zeynali 1 , 2 , Mehdi Nematbakhsh 1 , 3 , 4 , * , Hossain Mojtahedi 2 , Aliasghar Poorshahnazari 3 , Ardeshir Talebi 1 , 5 , Zahra Pezeshki 1 , Safoora Mazaheri 1 and Fatemeh Moslemi 1
Authors Information
1 Water and Electrolytes Research Center, Isfahan University of Medical Sciences, Isfahan, IR Iran
2 Department of Physical Education, Faculty of Physical Education, Isfahan University, Isfahan, IR Iran
3 Department of Physiology, Isfahan University of Medical Sciences, Isfahan, IR Iran
4 Isfahan -MN Institute of Basic and Applied Sciences Research, Isfahan, IR Iran
5 Department of Clinical Pathology, Isfahan University of Medical Sciences, Isfahan, IR Iran
Article information
  • Asian Journal of Sports Medicine: September 01, 2015, 6 (3); e24901
  • Published Online: September 28, 2015
  • Article Type: Research Article
  • Received: July 1, 2014
  • Accepted: October 22, 2014
  • DOI: 10.5812/asjsm.24901

To Cite: Zeynali F, Nematbakhsh M, Mojtahedi H, Poorshahnazari A, Talebi A, et al. Protective Role of Aerobic Exercise Against Cisplatin-Induced Nephrotoxicity in Rats, Asian J Sports Med. 2015 ; 6(3):e24901. doi: 10.5812/asjsm.24901.

Copyright © 2015, Sports Medicine Research Center. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Materials and Methods
4. Results
5. Discussion
  • 1. Ries F, Klastersky J. Nephrotoxicity induced by cancer chemotherapy with special emphasis on cisplatin toxicity. Am J Kidney Dis. 1986; 8(5): 368-79[PubMed]
  • 2. Espandiari P, Zhang J, Rosenzweig BA, Zhou Y, Vaidya VS, Schnackenberg L, et al. Age-Related Differences in Cisplatin-Induced Renal Toxicity in Rats. Faseb J. 2008; 22(1): 917
  • 3. Vansteenkiste J, Vandebroek J, Nackaerts K, Dooms C, Galdermans D, Bosquee L, et al. Influence of cisplatin-use, age, performance status and duration of chemotherapy on symptom control in advanced non-small cell lung cancer: detailed symptom analysis of a randomised study comparing cisplatin-vindesine to gemcitabine. Lung Cancer. 2003; 40(2): 191-9[PubMed]
  • 4. Hanigan MH, Devarajan P. Cisplatin nephrotoxicity: molecular mechanisms. Cancer Ther. 2003; 1: 47-61[PubMed]
  • 5. Fahmy H. Effect of Low Radiation Dose on Cisplatin Induced Hepato- Testicular Damage in Male Rats. Br J Pharm Res. 2014; 4(9): 1053-66[DOI]
  • 6. Nematbakhsh M, Nasri H. The effects of vitamin E and selenium on cisplatin-induced nephrotoxicity in cancer patients treated with cisplatin-based chemotherapy: A randomized, placebo-controlled study. J Res Med Sci. 2013; 18(7): 626-7[PubMed]
  • 7. Satoh M, Kashihara N, Fujimoto S, Horike H, Tokura T, Namikoshi T, et al. A novel free radical scavenger, edarabone, protects against cisplatin-induced acute renal damage in vitro and in vivo. J Pharmacol Exp Ther. 2003; 305(3): 1183-90[DOI][PubMed]
  • 8. Sugihara K, Nakano S, Koda M, Tanaka K, Fukuishi N, Gemba M. Stimulatory effect of cisplatin on production of lipid peroxidation in renal tissues. Jpn J Pharmacol. 1987; 43(3): 247-52[PubMed]
  • 9. Winston JA, Safirstein R. Reduced renal blood flow in early cisplatin-induced acute renal failure in the rat. Am J Physiol. 1985; 249(4 Pt 2)-6[PubMed]
  • 10. Ali BH, Al Moundhri MS. Agents ameliorating or augmenting the nephrotoxicity of cisplatin and other platinum compounds: a review of some recent research. Food Chem Toxicol. 2006; 44(8): 1173-83[DOI][PubMed]
  • 11. Nematbakhsh M, Ashrafi F, Safari T, Talebi A, Nasri H, Mortazavi M, et al. Administration of vitamin E and losartan as prophylaxes in cisplatin-induced nephrotoxicity model in rats. J Nephrol. 2012; 25(3): 410-7[DOI][PubMed]
  • 12. Ban M, Hettich D, Huguet N. Nephrotoxicity mechanism of cis-platinum (II) diamine dichloride in mice. Toxicol Lett. 1994; 71(2): 161-8[PubMed]
  • 13. Ajith TA, Abhishek G, Roshny D, Sudheesh NP. Co-supplementation of single and multi doses of vitamins C and E ameliorates cisplatin-induced acute renal failure in mice. Exp Toxicol Pathol. 2009; 61(6): 565-71[DOI][PubMed]
  • 14. Ajith TA, Usha S, Nivitha V. Ascorbic acid and alpha-tocopherol protect anticancer drug cisplatin induced nephrotoxicity in mice: a comparative study. Clin Chim Acta. 2007; 375(1-2): 82-6[DOI][PubMed]
  • 15. Miller RP, Tadagavadi RK, Ramesh G, Reeves WB. Mechanisms of Cisplatin nephrotoxicity. Toxins (Basel). 2010; 2(11): 2490-518[DOI][PubMed]
  • 16. Hayashi M, Numaguchi M, Watabe H, Enomoto H, Yaoi Y. Cisplatin-induced nephrotoxicity and the protective effect of fosfomycin on it as demonstrated by using a crossover study of urinary metabolite levels. Acta Obstet Gynecol Scand. 1997; 76(6): 590-5[PubMed]
  • 17. Duthie GG, Robertson JD, Maughan RJ, Morrice PC. Blood antioxidant status and erythrocyte lipid peroxidation following distance running. Arch Biochem Biophys. 1990; 282(1): 78-83[PubMed]
  • 18. Shin YA, Lee JH, Song W, Jun TW. Exercise training improves the antioxidant enzyme activity with no changes of telomere length. Mech Ageing Dev. 2008; 129(5): 254-60[DOI][PubMed]
  • 19. Berzosa C, Cebrian I, Fuentes-Broto L, Gomez-Trullen E, Piedrafita E, Martinez-Ballarin E, et al. Acute exercise increases plasma total antioxidant status and antioxidant enzyme activities in untrained men. J Biomed Biotechnol. 2011; 2011: 540458[DOI][PubMed]
  • 20. Naziroglu M, Simsek M, Kutlu M. Moderate exercise with a dietary vitamin C and E combination protects against streptozotocin-induced oxidative damage to the blood and improves fetal outcomes in pregnant rats. Clin Chem Lab Med. 2004; 42(5): 511-7[DOI][PubMed]
  • 21. Jacobsen PB, Phillips KM, Jim HS, Small BJ, Faul LA, Meade CD, et al. Effects of self-directed stress management training and home-based exercise on quality of life in cancer patients receiving chemotherapy: a randomized controlled trial. Psychooncology. 2013; 22(6): 1229-35[DOI][PubMed]
  • 22. Knutsen L, Quist M, Midtgaard J, Rorth M, Adamsen L. Maximum physical capacity testing in cancer patients undergoing chemotherapy: qualitative findings from an exercise program. Scand J Med Sci Sports. 2006; 16(6): 403-11[DOI][PubMed]
  • 23. Doyle C, Kushi LH, Byers T, Courneya KS, Demark-Wahnefried W, Grant B, et al. Nutrition and physical activity during and after cancer treatment: an American Cancer Society guide for informed choices. CA Cancer J Clin. 2006; 56(6): 323-53[PubMed]
  • 24. Baranowski M, Zabielski P, Blachnio-Zabielska AU, Harasiuk D, Gorski J. LXR activation prevents exhaustive exercise-induced hypoglycaemia and spares muscle glycogen but does not enhance running endurance in untrained rats. Acta Physiol (Oxf). 2011; 201(3): 373-9[DOI][PubMed]
  • 25. Powers SK, Criswell D, Lawler J, Martin D, Lieu FK, Ji LL, et al. Rigorous exercise training increases superoxide dismutase activity in ventricular myocardium. Am J Physiol. 1993; 265(6 Pt 2)-8[PubMed]
  • 26. Jilanchi S, Nematbakhsh M, Bahadorani M, Talebi A, Eshraghi-Jazi F, Mansouri A, et al. Vitamin e is a nephroprotectant agent in male but not in female in a model of Cisplatin-induced nephrotoxicity. ISRN Nephrol. 2013; 2013: 280395[DOI][PubMed]
  • 27. Antunes LM, Darin JD, Bianchi MD. Protective effects of vitamin c against cisplatin-induced nephrotoxicity and lipid peroxidation in adult rats: a dose-dependent study. Pharmacol Res. 2000; 41(4): 405-11[DOI][PubMed]
  • 28. De Martinis BS, Bianchi MD. Effect of vitamin C supplementation against cisplatin-induced toxicity and oxidative DNA damage in rats. Pharmacol Res. 2001; 44(4): 317-20[DOI][PubMed]
  • 29. Deegan PM, Nolan C, Ryan MP, Basinger MA, Jones MM, Hande KR. The role of the renin-angiotensin system in cisplatin nephrotoxicity. Ren Fail. 1995; 17(6): 665-74[PubMed]
  • 30. Saleh S, Ain-Shoka AA, El-Demerdash E, Khalef MM. Protective effects of the angiotensin II receptor blocker losartan on cisplatin-induced kidney injury. Chemotherapy. 2009; 55(6): 399-406[DOI][PubMed]
  • 31. Stakisaitis D, Dudeniene G, Jankunas RJ, Grazeliene G, Didziapetriene J, Pundziene B. Cisplatin increases urinary sodium excretion in rats: gender-related differences. Medicina (Kaunas). 2010; 46(1): 45-50[PubMed]
  • 32. Aleisa AM, Al-Majed AA, Al-Yahya AA, Al-Rejaie SS, Bakheet SA, Al-Shabanah OA, et al. Reversal of cisplatin-induced carnitine deficiency and energy starvation by propionyl-L-carnitine in rat kidney tissues. Clin Exp Pharmacol Physiol. 2007; 34(12): 1252-9[DOI][PubMed]
  • 33. Moinuddin I, Leehey DJ. A comparison of aerobic exercise and resistance training in patients with and without chronic kidney disease. Adv Chronic Kidney Dis. 2008; 15(1): 83-96[DOI][PubMed]
  • 34. Corpeleijn E, Bakker SJ, Stolk RP. Obesity and impaired renal function: potential for lifestyle intervention? Eur J Epidemiol. 2009; 24(6): 275-80[DOI][PubMed]
  • 35. Boor P, Celec P, Behuliak M, Grancic P, Kebis A, Kukan M, et al. Regular moderate exercise reduces advanced glycation and ameliorates early diabetic nephropathy in obese Zucker rats. Metabolism. 2009; 58(11): 1669-77[DOI][PubMed]
  • 36. Saleh S, El-Demerdash E. Protective effects of L-arginine against cisplatin-induced renal oxidative stress and toxicity: role of nitric oxide. Basic Clin Pharmacol Toxicol. 2005; 97(2): 91-7[DOI][PubMed]
  • 37. Moien-Afshari F, Ghosh S, Elmi S, Rahman MM, Sallam N, Khazaei M, et al. Exercise restores endothelial function independently of weight loss or hyperglycaemic status in db/db mice. Diabetologia. 2008; 51(7): 1327-37[DOI][PubMed]
  • 38. Alessio HM, Goldfarb AH. Lipid peroxidation and scavenger enzymes during exercise: adaptive response to training. J Appl Physiol (1985). 1988; 64(4): 1333-6[PubMed]
  • 39. Weijl NI, Elsendoorn TJ, Lentjes EG, Hopman GD, Wipkink-Bakker A, Zwinderman AH, et al. Supplementation with antioxidant micronutrients and chemotherapy-induced toxicity in cancer patients treated with cisplatin-based chemotherapy: a randomised, double-blind, placebo-controlled study. Eur J Cancer. 2004; 40(11): 1713-23[DOI][PubMed]
  • 40. Slentz CA, Duscha BD, Johnson JL, Ketchum K, Aiken LB, Samsa GP, et al. Effects of the amount of exercise on body weight, body composition, and measures of central obesity: STRRIDE--a randomized controlled study. Arch Intern Med. 2004; 164(1): 31-9[DOI][PubMed]
  • 41. Gao Y, Wang C, Pan T, Luo L. Impact of metformin treatment and swimming exercise on visfatin levels in high-fat-induced obesity rats. Arq Bras Endocrinol Metabol. 2014; 58(1): 42-7[PubMed]
  • 42. Kenney WL, Wilmore J, Costill D. Physiology of Sport and Exercise With Web Study Guide-5th Edition. 1999; : 710
  • 43. Nematbakhsh M, Ashrafi F, Nasri H, Talebi A, Pezeshki Z, Eshraghi F, et al. A model for prediction of cisplatin induced nephrotoxicity by kidney weight in experimental rats. J Res Med Sci. 2013; 18(5): 370-3[PubMed]
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