Asian Journal of Sports Medicine

Published by: Kowsar

Effects of Complementary Creatine Monohydrate and Physical Training on Inflammatory and Endothelial Dysfunction Markers Among Heart Failure Patients

Farajollah Hemati 1 , Asghar Rahmani 2 , Khairollah Asadollahi 3 , * , Koroush Soleimannejad 4 and Zahra Khalighi 5
Authors Information
1 Department of Sports Medicine, Faculty of Medicine, Ilam University of Medical Sciences, Ilam, IR Iran
2 Student Research Committee, Faculty of Medicine, Ilam University of Medical Sciences, Ilam, IR Iran
3 Department of Epidemiology, Faculty of Medicine, Ilam University of Medical Sciences, Ilam, IR Iran
4 Department of Cardiology, Faculty of Medicine, Ilam University of Medical Sciences, Ilam, IR Iran
5 Department of Internal Medicine, Faculty of Medicine, Ilam University of Medical Sciences, Ilam, IR Iran
Article information
  • Asian Journal of Sports Medicine: March 01, 2016, 7 (1); e28578
  • Published Online: March 5, 2016
  • Article Type: Research Article
  • Received: March 18, 2015
  • Revised: April 21, 2015
  • Accepted: May 19, 2015
  • DOI: 10.5812/asjsm.28578

To Cite: Hemati F, Rahmani A, Asadollahi K, Soleimannejad K, Khalighi Z. Effects of Complementary Creatine Monohydrate and Physical Training on Inflammatory and Endothelial Dysfunction Markers Among Heart Failure Patients, Asian J Sports Med. 2016 ; 7(1):e28578. doi: 10.5812/asjsm.28578.

Copyright © 2016, Sports Medicine Research Center. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Patients and Methods
4. Results
5. Discussion
  • 1. Soukoulis V, Dihu JB, Sole M, Anker SD, Cleland J, Fonarow GC, et al. Micronutrient deficiencies an unmet need in heart failure. J Am Coll Cardiol. 2009; 54(18): 1660-73[DOI][PubMed]
  • 2. Lloyd-Jones DM, Larson MG, Leip EP, Beiser A, D'Agostino RB, Kannel WB, et al. Lifetime risk for developing congestive heart failure: the Framingham Heart Study. Circulation. 2002; 106(24): 3068-72[PubMed]
  • 3. Butler J, Kalogeropoulos A, Georgiopoulou V, Belue R, Rodondi N, Garcia M, et al. Incident heart failure prediction in the elderly: the health ABC heart failure score. Circ Heart Fail. 2008; 1(2): 125-33[DOI][PubMed]
  • 4. Marchionni N, Di Bari M, Fumagalli S, Ferrucci L, Baldereschi G, Timpanelli M, et al. Variable effect of comorbidity on the association of chronic cardiac failure with disability in community-dwelling older persons. Arch Gerontol Geriatr. 1996; 23(3): 283-92[DOI]
  • 5. Masoudi FA, Rumsfeld JS, Havranek EP, House JA, Peterson ED, Krumholz HM, et al. Age, functional capacity, and health-related quality of life in patients with heart failure. J Card Fail. 2004; 10(5): 368-73[PubMed]
  • 6. Rodriguez-Artalejo F, Guallar-Castillon P, Pascual CR, Otero CM, Montes AO, Garcia AN, et al. Health-related quality of life as a predictor of hospital readmission and death among patients with heart failure. Arch Intern Med. 2005; 165(11): 1274-9[DOI][PubMed]
  • 7. Heo S, Moser DK, Lennie TA, Zambroski CH, Chung ML. A comparison of health-related quality of life between older adults with heart failure and healthy older adults. Heart Lung. 2007; 36(1): 16-24[DOI][PubMed]
  • 8. Witte KKA, Clark AL, Cleland JGF. Chronic heart failure and micronutrients. J Am College Cardiol. 2001; 37(7): 1765-74[DOI]
  • 9. Berezin AE, Kremzer AA, Samura TA, Martovitskaya YV. Circulating endothelial-derived apoptotic microparticles in the patients with ischemic symptomatic chronic heart failure: relevance of pro-inflammatory activation and outcomes. Int Cardiovasc Res J. 2014; 8(3): 116-23[PubMed]
  • 10. Badavi M, Abedi HA, Sarkaki AR, Dianat M. Co-administration of Grape Seed Extract and Exercise Training Improves Endothelial Dysfunction of Coronary Vascular Bed of STZ-Induced Diabetic Rats. Iran Red Crescent Med J. 2013; 15(10)[DOI][PubMed]
  • 11. Michowitz Y, Arbel Y, Wexler D, Sheps D, Rogowski O, Shapira I, et al. Predictive value of high sensitivity CRP in patients with diastolic heart failure. Int J Cardiol. 2008; 125(3): 347-51[DOI][PubMed]
  • 12. Shah SJ, Marcus GM, Gerber IL, McKeown BH, Vessey JC, Jordan MV, et al. High-sensitivity C-reactive protein and parameters of left ventricular dysfunction. J Card Fail. 2006; 12(1): 61-5[DOI][PubMed]
  • 13. Vescovo G, Ravara B, Gobbo V, Sandri M, Angelini A, Della Barbera M, et al. L-Carnitine: a potential treatment for blocking apoptosis and preventing skeletal muscle myopathy in heart failure. Am J Physiol Cell Physiol. 2002; 283(3)-10[DOI][PubMed]
  • 14. Tulchinsky TH. Micronutrient deficiency conditions: global health issues. Public Health Rev. 2010; 32(1): 243-55
  • 15. Felker GM. Coenzyme Q10 and statins in heart failure: the dog that didn't bark. J Am Coll Cardiol. 2010; 56(15): 1205-6[DOI][PubMed]
  • 16. Wyss M, Kaddurah-Daouk R. Creatine and creatinine metabolism. Physiol Rev. 2000; 80(3): 1107-213[PubMed]
  • 17. Persky AM, Brazeau GA. Clinical pharmacology of the dietary supplement creatine monohydrate. Pharmacol Rev. 2001; 53(2): 161-76[PubMed]
  • 18. Ferraro S, Maddalena G, Fazio S, Santomauro M, Lo Storto M, Codella C, et al. Acute and short-term efficacy of high doses of creatine phosphate in the treatment of cardiac failure. Current Ther Res. 1990; 47(6): 917-23
  • 19. Mancini DM, Ferraro N, Tuchler M, Chance B, Wilson JR. Detection of abnormal calf muscle metabolism in patients with heart failure using phosphorus-31 nuclear magnetic resonance. Am J Cardiol. 1988; 62(17): 1234-40[DOI]
  • 20. Kuethe F, Krack A, Richartz BM, Figulla HR. Creatine supplementation improves muscle strength in patients with congestive heart failure. Pharmazie. 2006; 61(3): 218-22[PubMed]
  • 21. Gordon A, Hultman E, Kaijser L, Kristjansson S, Rolf CJ, Nyquist O, et al. Creatine supplementation in chronic heart failure increases skeletal muscle creatine phosphate and muscle performance. Cardiovasc Res. 1995; 30(3): 413-8[DOI]
  • 22. Weiss RG, Gerstenblith G, Bottomley PA. ATP flux through creatine kinase in the normal, stressed, and failing human heart. Proc Natl Acad Sci U S A. 2005; 102(3): 808-13[DOI][PubMed]
  • 23. Horjus DL, Oudman I, van Montfrans GA, Brewster LM, Horjus DL. Creatine and creatine analogues in hypertension and cardiovascular disease. Cochrane Database Syst Rev. 2011; 9(11)[DOI]
  • 24. Wenger NK. Current status of cardiac rehabilitation. J Am Coll Cardiol. 2008; 51(17): 1619-31[DOI][PubMed]
  • 25. Hosseini MA, Mandegar H, Zand BM. Assessment the effects of cardiac rehabilitation program on occurance of clinical manifestation and rehospitalization of patients after coronary bypass grafting surgery [Persian]. J Ahwaz Uni Medi Sci. 2004; 39(4): 7-12
  • 26. O'Connor GT, Buring JE, Yusuf S, Goldhaber SZ, Olmstead EM, Paffenbarger RS, et al. An overview of randomized trials of rehabilitation with exercise after myocardial infarction. Circulation. 1989; 80(2): 234-44[PubMed]
  • 27. Erbs S, Hollriegel R, Linke A, Beck EB, Adams V, Gielen S, et al. Exercise training in patients with advanced chronic heart failure (NYHA IIIb) promotes restoration of peripheral vasomotor function, induction of endogenous regeneration, and improvement of left ventricular function. Circ Heart Fail. 2010; 3(4): 486-94[DOI][PubMed]
  • 28. Pashkow FJ. Clinical cardiac rehabilitation: a cardiologist's guide. 1993;
  • 29. Guidelines for Cardiac Rehabilitation and Secondary Prevention Programs. 2003;
  • 30. Tarnopolsky MA. The mitochondrial cocktail: rationale for combined nutraceutical therapy in mitochondrial cytopathies. Adv Drug Deliv Rev. 2008; 60(13-14): 1561-7[DOI][PubMed]
  • 31. Witte KK, Clark AL. Micronutrients and their supplementation in chronic cardiac failure. An update beyond theoretical perspectives. Heart Fail Rev. 2006; 11(1): 65-74[DOI][PubMed]
  • 32. Allard ML, Jeejeebhoy KN, Sole MJ. The management of conditioned nutritional requirements in heart failure. Heart Fail Rev. 2006; 11(1): 75-82[DOI][PubMed]
  • 33. Witte KK, Nikitin NP, Parker AC, von Haehling S, Volk HD, Anker SD, et al. The effect of micronutrient supplementation on quality-of-life and left ventricular function in elderly patients with chronic heart failure. Eur Heart J. 2005; 26(21): 2238-44[DOI][PubMed]
  • 34. Linke A, Adams V, Schulze PC, Erbs S, Gielen S, Fiehn E, et al. Antioxidative effects of exercise training in patients with chronic heart failure: increase in radical scavenger enzyme activity in skeletal muscle. Circulation. 2005; 111(14): 1763-70[DOI][PubMed]
  • 35. Hambrecht R, Fiehn E, Weigl C, Gielen S, Hamann C, Kaiser R, et al. Regular Physical Exercise Corrects Endothelial Dysfunction and Improves Exercise Capacity in Patients With Chronic Heart Failure. Circulation. 1998; 98(24): 2709-15[DOI]
  • 36. Batista Junior ML, Lopes RD, Seelaender MC, Lopes AC. Anti-inflammatory effect of physical training in heart failure: role of TNF-alpha and IL-10. Arq Bras Cardiol. 2009; 93(6): 643-51[PubMed]
  • 37. Fu TC, Wang CH, Lin PS, Hsu CC, Cherng WJ, Huang SC, et al. Aerobic interval training improves oxygen uptake efficiency by enhancing cerebral and muscular hemodynamics in patients with heart failure. Int J Cardiol. 2013; 167(1): 41-50[DOI][PubMed]
  • 38. Schaufelberger M, Eriksson BO, Held P, Swedberg K. Skeletal muscle metabolism during exercise in patients with chronic heart failure. Heart. 1996; 76(1): 29-34[DOI]
  • 39. Andrews R. The effect of dietary creatine supplementation on skeletal muscle metabolism in congestive heart failure. Eur Heart J. 1998; 19(4): 617-22[DOI]
Creative Commons License Except where otherwise noted, this work is licensed under Creative Commons Attribution Non Commercial 4.0 International License .

Search Relations:



Create Citiation Alert
via Google Reader

Readers' Comments