Asian Journal of Sports Medicine

Published by: Kowsar

Acute Cardiovascular and Hemodynamic Responses to Low Intensity Eccentric Resistance Exercise with Blood Flow Restriction

Behzad Bazgir 1 , 2 , Mojtaba Rezazadeh Valojerdi 2 , 3 , Hamid Rajabi 4 , Rouhollah Fathi 2 , Seyed Mojtaba Ojaghi 5 , Mohammad Kazem Emami Meybodi 6 , Gabriel R. Neto 7 , Mostafa Rahimi 8 and Alireza Asgari 1 , 9 , *
Authors Information
1 Exercise Physiology Research Center, Baqiyatallah University of Medical Sciences, Tehran, IR Iran
2 Department of Embryology, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, IR Iran
3 Department of Anatomy, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, IR Iran
4 Department of Exercise Physiology, Faculty of Physical Education and Sport Sciences, Kharazmi University, Tehran, IR Iran
5 Rehabilitation Center of National Sports Medicine Federation, Tehran, IR Iran
6 Orthopedic Department and Trauma Research Center, Baqiyatallah University of Medical Sciences, Tehran, IR Iran
7 Department of Physical Education, Associate Graduate Program in Physical Education UPE / UFPB, Joao Pessoa, Paraiba, Brazil
8 Department of Physical Education and Sport Sciences, Human Science Faculty, University of Kashan, Kashan, IR Iran
9 Aerospace and Subaquatic Medicine Faculty, Aerospace Medicine Research Center, AJA University of Medical Sciences, Tehran, IR Iran
Article information
  • Asian Journal of Sports Medicine: December 01, 2016, 7 (4); e38458
  • Published Online: September 14, 2016
  • Article Type: Research Article
  • Received: April 13, 2016
  • Revised: August 2, 2016
  • Accepted: August 20, 2016
  • DOI: 10.5812/asjsm.38458

To Cite: Bazgir B, Rezazadeh Valojerdi M, Rajabi H, Fathi R, Ojaghi S M, et al. Acute Cardiovascular and Hemodynamic Responses to Low Intensity Eccentric Resistance Exercise with Blood Flow Restriction, Asian J Sports Med. 2016 ; 7(4):e38458. doi: 10.5812/asjsm.38458.

Copyright © 2016, Sports Medicine Research Center. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Methods
4. Results
5. Discussion
  • 1. WHO Fact sheet . Cardiovascular diseases (CVDs). 2015;
  • 2. Myers J, Prakash M, Froelicher V, Do D, Partington S, Atwood JE. Exercise capacity and mortality among men referred for exercise testing. N Engl J Med. 2002; 346(11): 793-801[DOI][PubMed]
  • 3. Nocon M, Hiemann T, Muller-Riemenschneider F, Thalau F, Roll S, Willich SN. Association of physical activity with all-cause and cardiovascular mortality: a systematic review and meta-analysis. Eur J Cardiovasc Prev Rehabil. 2008; 15(3): 239-46[DOI][PubMed]
  • 4. Smith DL, Fernhall B. Advanced cardiovascular exercise physiology. 2011;
  • 5. Collier SR, Kanaley JA, Carhart RJ, Frechette V, Tobin MM, Hall AK, et al. Effect of 4 weeks of aerobic or resistance exercise training on arterial stiffness, blood flow and blood pressure in pre- and stage-1 hypertensives. J Hum Hypertens. 2008; 22(10): 678-86[DOI][PubMed]
  • 6. American College of Sports M. American College of Sports Medicine position stand. Progression models in resistance training for healthy adults. Med Sci Sports Exerc. 2009; 41(3): 687-708[DOI][PubMed]
  • 7. Pollock ML, Franklin BA, Balady GJ, Chaitman BL, Fleg JL, Fletcher B, et al. AHA Science Advisory. Resistance exercise in individuals with and without cardiovascular disease: benefits, rationale, safety, and prescription: An advisory from the Committee on Exercise, Rehabilitation, and Prevention, Council on Clinical Cardiology, American Heart Association; Position paper endorsed by the American College of Sports Medicine. Circulation. 2000; 101(7): 828-33[PubMed]
  • 8. Loenneke JP, Wilson JM, Balapur A, Thrower AD, Barnes JT, Pujol TJ. Time under tension decreased with blood flow-restricted exercise. Clin Physiol Funct Imaging. 2012; 32(4): 268-73[DOI][PubMed]
  • 9. Laurentino GC, Ugrinowitsch C, Roschel H, Aoki MS, Soares AG, Neves MJ, et al. Strength training with blood flow restriction diminishes myostatin gene expression. Med Sci Sports Exerc. 2012; 44(3): 406-12[DOI][PubMed]
  • 10. Scott BR, Loenneke JP, Slattery KM, Dascombe BJ. Exercise with blood flow restriction: an updated evidence-based approach for enhanced muscular development. Sports Med. 2015; 45(3): 313-25[DOI][PubMed]
  • 11. Takano H, Morita T, Iida H, Asada K, Kato M, Uno K, et al. Hemodynamic and hormonal responses to a short-term low-intensity resistance exercise with the reduction of muscle blood flow. Eur J Appl Physiol. 2005; 95(1): 65-73[DOI][PubMed]
  • 12. Fahs CA, Rossow LM, Seo DI, Loenneke JP, Sherk VD, Kim E, et al. Effect of different types of resistance exercise on arterial compliance and calf blood flow. Eur J Appl Physiol. 2011; 111(12): 2969-75[DOI][PubMed]
  • 13. Neto GR, Sousa MS, Costa PB, Salles BF, Novaes GS, Novaes JS. Hypotensive effects of resistance exercises with blood flow restriction. J Strength Cond Res. 2015; 29(4): 1064-70[DOI][PubMed]
  • 14. Neto GR, Santos HH, Sousa JB, Junior AT, Araujo JP, Aniceto RR, et al. Effects of high-intensity blood flow restriction exercise on muscle fatigue. J Hum Kinet. 2014; 41: 163-72[DOI][PubMed]
  • 15. Vieira PJ, Chiappa GR, Umpierre D, Stein R, Ribeiro JP. Hemodynamic responses to resistance exercise with restricted blood flow in young and older men. J Strength Cond Res. 2013; 27(8): 2288-94[DOI][PubMed]
  • 16. Kubota N, Takano H, Tsutsumi T, Kurano M, Iida H, Yasuda T, et al. Resistance exercise combined with KAATSU during simulated weightlessness. Int J KAATSU Train Res. 2008; 4(1): 9-15
  • 17. Pinto RR, Polito MD. Haemodynamic responses during resistance exercise with blood flow restriction in hypertensive subjects. Clin Physiol Funct Imaging. 2016; 36(5): 407-13[DOI][PubMed]
  • 18. Yasuda T, Fukumura K, Fukuda T, Iida H, Imuta H, Sato Y, et al. Effects of low-intensity, elastic band resistance exercise combined with blood flow restriction on muscle activation. Scand J Med Sci Sports. 2014; 24(1): 55-61[DOI][PubMed]
  • 19. Beck TW. The importance of a priori sample size estimation in strength and conditioning research. J Strength Cond Res. 2013; 27(8): 2323-37[DOI][PubMed]
  • 20. Aagaard P, Andersen JL, Dyhre-Poulsen P, Leffers AM, Wagner A, Magnusson SP, et al. A mechanism for increased contractile strength of human pennate muscle in response to strength training: changes in muscle architecture. J Physiol. 2001; 534: 613-23[PubMed]
  • 21. Nielsen JL, Aagaard P, Bech RD, Nygaard T, Hvid LG, Wernbom M, et al. Proliferation of myogenic stem cells in human skeletal muscle in response to low-load resistance training with blood flow restriction. J Physiol. 2012; 590(17): 4351-61[DOI][PubMed]
  • 22. Marocolo M, Willardson JM, Marocolo IC, Ribeiro da Mota G, Simao R, Maior AS. Ischemic Preconditioning and Placebo Intervention Improves Resistance Exercise Performance. J Strength Cond Res. 2016; 30(5): 1462-9[DOI][PubMed]
  • 23. Iida H, Kurano M, Takano H, Kubota N, Morita T, Meguro K, et al. Hemodynamic and neurohumoral responses to the restriction of femoral blood flow by KAATSU in healthy subjects. Eur J Appl Physiol. 2007; 100(3): 275-85[DOI][PubMed]
  • 24. Takarada Y, Takazawa H, Sato Y, Takebayashi S, Tanaka Y, Ishii N. Effects of resistance exercise combined with moderate vascular occlusion on muscular function in humans. J Appl Physiol (1985). 2000; 88(6): 2097-106[PubMed]
  • 25. de Greeff A, Shennan AH. The Rossmax (ME 701 series) upper arm device: accuracy assessment in an adult population according to the International and the British Hypertension Society protocols. Blood Press Monit. 2008; 13(1): 43-8[DOI][PubMed]
  • 26. Hall JE. Guyton and Hall textbook of medical physiology. 2015;
  • 27. Thiebaud RS, Yasuda T, Loenneke JP, Abe T. Effects of low-intensity concentric and eccentric exercise combined with blood flow restriction on indices of exercise-induced muscle damage. Interv Med Appl Sci. 2013; 5(2): 53-9[DOI][PubMed]
  • 28. Loenneke JP, Kearney ML, Thrower AD, Collins S, Pujol TJ. The acute response of practical occlusion in the knee extensors. J Strength Cond Res. 2010; 24(10): 2831-4[DOI][PubMed]
  • 29. Yasuda T, Fukumura K, Fukuda T, Uchida Y, Iida H, Meguro M, et al. Muscle size and arterial stiffness after blood flow-restricted low-intensity resistance training in older adults. Scand J Med Sci Sports. 2014; 24(5): 799-806[DOI][PubMed]
  • 30. Ghilarducci LE, Holly RG, Amsterdam EA. Effects of high resistance training in coronary artery disease. Am J Cardiol. 1989; 64(14): 866-70[PubMed]
  • 31. Neto GR, Sousa MS, Costa e Silva GV, Gil AL, Salles BF, Novaes JS. Acute resistance exercise with blood flow restriction effects on heart rate, double product, oxygen saturation and perceived exertion. Clin Physiol Funct Imaging. 2016; 36(1): 53-9[DOI][PubMed]
  • 32. MacDougall JD, Tuxen D, Sale DG, Moroz JR, Sutton JR. Arterial blood pressure response to heavy resistance exercise. J Appl Physiol (1985). 1985; 58(3): 785-90[PubMed]
  • 33. Figueroa A, Vicil F. Post-exercise aortic hemodynamic responses to low-intensity resistance exercise with and without vascular occlusion. Scand J Med Sci Sports. 2011; 21(3): 431-6[DOI][PubMed]
  • 34. Hayes SG, Kindig AE, Kaufman MP. Comparison between the effect of static contraction and tendon stretch on the discharge of group III and IV muscle afferents. J Appl Physiol (1985). 2005; 99(5): 1891-6[DOI][PubMed]
  • 35. Fisher JP, Bell MP, White MJ. Cardiovascular responses to human calf muscle stretch during varying levels of muscle metaboreflex activation. Exp Physiol. 2005; 90(5): 773-81[DOI][PubMed]
  • 36. Loenneke JP, Wilson GJ, Wilson JM. A mechanistic approach to blood flow occlusion. Int J Sports Med. 2010; 31(1): 1-4[DOI][PubMed]
  • 37. Wernbom M, Jarrebring R, Andreasson MA, Augustsson J. Acute effects of blood flow restriction on muscle activity and endurance during fatiguing dynamic knee extensions at low load. J Strength Cond Res. 2009; 23(8): 2389-95[DOI][PubMed]
  • 38. Loenneke JP, Thiebaud RS, Fahs CA, Rossow LM, Abe T, Bemben MG. Blood flow restriction does not result in prolonged decrements in torque. Eur J Appl Physiol. 2013; 113(4): 923-31[DOI][PubMed]
  • 39. Vieira A, Gadelha AB, Ferreira-Junior JB, Vieira CA, Soares Ede M, Cadore EL, et al. Session rating of perceived exertion following resistance exercise with blood flow restriction. Clin Physiol Funct Imaging. 2015; 35(5): 323-7[DOI][PubMed]
Creative Commons License Except where otherwise noted, this work is licensed under Creative Commons Attribution Non Commercial 4.0 International License .

Search Relations:



Create Citiation Alert
via Google Reader

Readers' Comments