Asian Journal of Sports Medicine

Published by: Kowsar

Effects of Quercetin Supplementation on Exercise Induced Inflammation and Immune Cell Changes After Exhausting Swimming in Adolescent Girls

Mandana Gholami 1 , * and Mahia Ardestani 1
Authors Information
1 Department of Physical Education and Sport Science, Science and Research Branch, Islamic Azad University, Tehran, Iran
Article information
  • Asian Journal of Sports Medicine: September 2018, 9 (3); e60157
  • Published Online: September 2, 2018
  • Article Type: Research Article
  • Received: August 13, 2017
  • Revised: May 8, 2018
  • Accepted: May 18, 2018
  • DOI: 10.5812/asjsm.60157

To Cite: Gholami M, Ardestani M. Effects of Quercetin Supplementation on Exercise Induced Inflammation and Immune Cell Changes After Exhausting Swimming in Adolescent Girls, Asian J Sports Med. 2018 ; 9(3):e60157. doi: 10.5812/asjsm.60157.

Abstract
Copyright © 2018, Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Methods
4. Results
5. Discussion
Acknowledgements
References
  • 1. Sanchez-Matamoros A, Kukielka D, De las Heras AI, Sanchez-Vizcaino JM. Development and evaluation of a SYBR Green real-time RT-PCR assay for evaluation of cytokine gene expression in horse. Cytokine. 2013;61(1):50-3. doi: 10.1016/j.cyto.2012.10.004. [PubMed: 23103121].
  • 2. Heled Y, Fleischmann C, Epstein Y. Cytokines and their role in hyperthermia and heat stroke. J Basic Clin Physiol Pharmacol. 2013;24(2):85-96. doi: 10.1515/jbcpp-2012-0040. [PubMed: 23509213].
  • 3. Popa C, Netea MG, van Riel PL, van der Meer JW, Stalenhoef AF. The role of TNF-alpha in chronic inflammatory conditions, intermediary metabolism, and cardiovascular risk. J Lipid Res. 2007;48(4):751-62. doi: 10.1194/jlr.R600021-JLR200. [PubMed: 17202130].
  • 4. Cleto LS, Oleto AF, Sousa LP, Barreto TO, Cruz JS, Penaforte CL, et al. Plasma cytokine response, lipid peroxidation and NF-kB activation in skeletal muscle following maximum progressive swimming. Braz J Med Biol Res. 2011;44(6):546-52. [PubMed: 21519639].
  • 5. Rahman ZA, Abdullah N, Singh R, Sosroseno W. Effect of acute exercise on the levels of salivary cortisol, tumor necrosis factor-alpha and nitric oxide. J Oral Sci. 2010;52(1):133-6. [PubMed: 20339244].
  • 6. Ostrowski K, Rohde T, Asp S, Schjerling P, Pedersen BK. Pro- and anti-inflammatory cytokine balance in strenuous exercise in humans. J Physiol. 1999;515 ( Pt 1):287-91. [PubMed: 9925898]. [PubMed Central: PMC2269132].
  • 7. Nemet D, Oh Y, Kim HS, Hill M, Cooper DM. Effect of intense exercise on inflammatory cytokines and growth mediators in adolescent boys. Pediatrics. 2002;110(4):681-9. [PubMed: 12359780].
  • 8. Kasapis C, Thompson PD. The effects of physical activity on serum C-reactive protein and inflammatory markers: a systematic review. J Am Coll Cardiol. 2005;45(10):1563-9. doi: 10.1016/j.jacc.2004.12.077. [PubMed: 15893167].
  • 9. Bernecker C, Scherr J, Schinner S, Braun S, Scherbaum WA, Halle M. Evidence for an exercise induced increase of TNF-alpha and IL-6 in marathon runners. Scand J Med Sci Sports. 2013;23(2):207-14. doi: 10.1111/j.1600-0838.2011.01372.x. [PubMed: 22092703].
  • 10. Pedersen BK, Hoffman-Goetz L. Exercise and the immune system: regulation, integration, and adaptation. Physiol Rev. 2000;80(3):1055-81. doi: 10.1152/physrev.2000.80.3.1055. [PubMed: 10893431].
  • 11. Febbraio MA, Pedersen BK. Muscle-derived interleukin-6: mechanisms for activation and possible biological roles. FASEB J. 2002;16(11):1335-47. doi: 10.1096/fj.01-0876rev. [PubMed: 12205025].
  • 12. Simpson RJ, Kunz H, Agha N, Graff R. Exercise and the Regulation of Immune Functions. Prog Mol Biol Transl Sci. 2015;135:355-80. doi: 10.1016/bs.pmbts.2015.08.001. [PubMed: 26477922].
  • 13. Nieman DC, Bishop NC. Nutritional strategies to counter stress to the immune system in athletes, with special reference to football. J Sports Sci. 2006;24(7):763-72. doi: 10.1080/02640410500482982. [PubMed: 16766504].
  • 14. Boots AW, Drent M, de Boer VC, Bast A, Haenen GR. Quercetin reduces markers of oxidative stress and inflammation in sarcoidosis. Clin Nutr. 2011;30(4):506-12. doi: 10.1016/j.clnu.2011.01.010. [PubMed: 21324570].
  • 15. Dumke CL, Nieman DC, Utter AC, Rigby MD, Quindry JC, Triplett NT, et al. Quercetin's effect on cycling efficiency and substrate utilization. Appl Physiol Nutr Metab. 2009;34(6):993-1000. doi: 10.1139/H09-099. [PubMed: 20029506].
  • 16. Leelayuwat N, Laddawan S, Kanpetta Y, Benja M, Wongpan D, Tunkamnerdthai O, et al. Quercetin enhances endurance capacity via antioxidant activity and size of muscle fibre type 1. J Pharm Nutr Sci. 2012;2(2):160-4. doi: 10.6000/1927-5951.2012.02.02.7.
  • 17. Nieman DC, Henson DA, Davis JM, Dumke CL, Gross SJ, Jenkins DP, et al. Quercetin ingestion does not alter cytokine changes in athletes competing in the Western States Endurance Run. J Interferon Cytokine Res. 2007;27(12):1003-11. doi: 10.1089/jir.2007.0050. [PubMed: 18184041].
  • 18. Konrad M, Nieman DC, Henson DA, Kennerly KM, Jin F, Wallner-Liebmann SJ. The acute effect of ingesting a quercetin-based supplement on exercise-induced inflammation and immune changes in runners. Int J Sport Nutr Exerc Metab. 2011;21(4):338-46. [PubMed: 21813917].
  • 19. Nieman DC, Henson DA, Davis JM, Angela Murphy E, Jenkins DP, Gross SJ, et al. Quercetin's influence on exercise-induced changes in plasma cytokines and muscle and leukocyte cytokine mRNA. J Appl Physiol (1985). 2007;103(5):1728-35. doi: 10.1152/japplphysiol.00707.2007. [PubMed: 17717114].
  • 20. McAnulty LS, Miller LE, Hosick PA, Utter AC, Quindry JC, McAnulty SR. Effect of resveratrol and quercetin supplementation on redox status and inflammation after exercise. Appl Physiol Nutr Metab. 2013;38(7):760-5. doi: 10.1139/apnm-2012-0455. [PubMed: 23980734].
  • 21. Penry JT, Wilcox AR, Yun J. Validity and reliability analysis of Cooper's 12-minute run and the multistage shuttle run in healthy adults. J Strength Cond Res. 2011;25(3):597-605. doi: 10.1519/JSC.0b013e3181cc2423. [PubMed: 20647946].
  • 22. Cooper KH. A means of assessing maximal oxygen intake. Correlation between field and treadmill testing. JAMA. 1968;203(3):201-4. [PubMed: 5694044].
  • 23. Daneshvar P, Hariri M, Ghiasvand R, Askari G, Darvishi L, Mashhadi NS, et al. Effect of eight weeks of quercetin supplementation on exercise performance, muscle damage and body muscle in male badminton players. Int J Prev Med. 2013;4(Suppl 1):S53-7. [PubMed: 23717771]. [PubMed Central: PMC3665027].
  • 24. Nieman DC, Henson DA, McAnulty SR, Jin F, Maxwell KR. n-3 polyunsaturated fatty acids do not alter immune and inflammation measures in endurance athletes. Int J Sport Nutr Exerc Metab. 2009;19(5):536-46. [PubMed: 19910654].
  • 25. Gao C, Chen X, Li J, Li Y, Tang Y, Liu L, et al. Myocardial mitochondrial oxidative stress and dysfunction in intense exercise: regulatory effects of quercetin. Eur J Appl Physiol. 2014;114(4):695-705. doi: 10.1007/s00421-013-2802-9. [PubMed: 24368555].
  • 26. Nieman DC. Quercetin's bioactive effects in human athletes. Curr Top Nutraceut R. 2010;8(1):33.
  • 27. MacRae HS, Mefferd KM. Dietary antioxidant supplementation combined with quercetin improves cycling time trial performance. Int J Sport Nutr Exerc Metab. 2006;16(4):405-19. [PubMed: 17136942].
  • 28. Phillips T, Childs AC, Dreon DM, Phinney S, Leeuwenburgh C. A dietary supplement attenuates IL-6 and CRP after eccentric exercise in untrained males. Med Sci Sports Exerc. 2003;35(12):2032-7. doi: 10.1249/01.MSS.0000099112.32342.10. [PubMed: 14652498].
  • 29. Zahedi M, Ghiasvand R, Feizi A, Asgari G, Darvish L. Does Quercetin Improve Cardiovascular Risk factors and Inflammatory Biomarkers in Women with Type 2 Diabetes: A Double-blind Randomized Controlled Clinical Trial. Int J Prev Med. 2013;4(7):777-85. [PubMed: 24049596]. [PubMed Central: PMC3775217].
  • 30. Paul AT, Gohil VM, Bhutani KK. Modulating TNF-alpha signaling with natural products. Drug Discov Today. 2006;11(15-16):725-32. doi: 10.1016/j.drudis.2006.06.002. [PubMed: 16846800].
  • 31. Granado-Serrano AB, Martin MA, Bravo L, Goya L, Ramos S. Quercetin attenuates TNF-induced inflammation in hepatic cells by inhibiting the NF-kappaB pathway. Nutr Cancer. 2012;64(4):588-98. doi: 10.1080/01635581.2012.661513. [PubMed: 22452660].
  • 32. O'Fallon KS, Kaushik D, Michniak-Kohn B, Dunne CP, Zambraski EJ, Clarkson PM. Effects of quercetin supplementation on markers of muscle damage and inflammation after eccentric exercise. Int J Sport Nutr Exerc Metab. 2012;22(6):430-7. [PubMed: 22805422].
  • 33. Ganio MS, Armstrong LE, Johnson EC, Klau JF, Ballard KD, Michniak-Kohn B, et al. Effect of quercetin supplementation on maximal oxygen uptake in men and women. J Sports Sci. 2010;28(2):201-8. doi: 10.1080/02640410903428558. [PubMed: 20054739].
  • 34. Comalada M, Camuesco D, Sierra S, Ballester I, Xaus J, Galvez J, et al. In vivo quercitrin anti-inflammatory effect involves release of quercetin, which inhibits inflammation through down-regulation of the NF-kappaB pathway. Eur J Immunol. 2005;35(2):584-92. doi: 10.1002/eji.200425778. [PubMed: 15668926].
  • 35. Nair MP, Kandaswami C, Mahajan S, Chadha KC, Chawda R, Nair H, et al. The flavonoid, quercetin, differentially regulates Th-1 (IFNgamma) and Th-2 (IL4) cytokine gene expression by normal peripheral blood mononuclear cells. Biochim Biophys Acta. 2002;1593(1):29-36. [PubMed: 12431781].
  • 36. Ahn J, Lee H, Kim S, Park J, Ha T. The anti-obesity effect of quercetin is mediated by the AMPK and MAPK signaling pathways. Biochem Biophys Res Commun. 2008;373(4):545-9. doi: 10.1016/j.bbrc.2008.06.077. [PubMed: 18586010].
Creative Commons License Except where otherwise noted, this work is licensed under Creative Commons Attribution Non Commercial 4.0 International License .
Readers' Comments