Asian Journal of Sports Medicine

Published by: Kowsar

Novel Kidney Injury Biomarkers Among Anabolic Androgenic Steroids Users - Evidence of Subclinical Kidney Disease

Elizabeth de Francesco Daher 1 , * , Paulo Henrique Palacio Duarte Fernandes 1 , Gdayllon Cavalcante Meneses 2 , Gabriela Freire Bezerra 2 , Leonardo de Souza Lima Ferreira 1 , Glautemberg de Almeida Viana 1 , Alice Maria Costa Martins 2 and Geraldo Bezerra da Silva Junior 3
Authors Information
1 Medical Sciences Graduate Program, Department of Internal Medicine, School of Medicine, Federal University of Ceara, Fortaleza, Ceara, Brazil
2 Department of Physiology and Pharmacology, Pharmacology Graduate Program, School of Medicine, Federal University of Ceara, Fortaleza, Ceara, Brazil
3 Public Health Graduate Program, Health Sciences Center, University of Fortaleza. Fortaleza, Ceara, Brazil
Article information
  • Asian Journal of Sports Medicine: March 2018, 9 (1); e65540
  • Published Online: January 10, 2018
  • Article Type: Brief Report
  • Received: February 24, 2017
  • Accepted: August 20, 2017
  • DOI: 10.5812/asjsm.65540

To Cite: Francesco Daher E D, Palacio Duarte Fernandes P H, Cavalcante Meneses G, Freire Bezerra G, Souza Lima Ferreira L D, et al. Novel Kidney Injury Biomarkers Among Anabolic Androgenic Steroids Users - Evidence of Subclinical Kidney Disease, Asian J Sports Med. 2018 ; 9(1):e65540. doi: 10.5812/asjsm.65540.

Copyright © 2018, Asian Journal of Sports Medicine. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited
1. Background
2. Methods
3. Results
4. Discussion
  • 1. Pope HGJ, Khalsa JH, Bhasin S. Body image disorders and abuse of anabolic androgenic steroids among men. JAMA. 2017;317(1):23-4. doi: 10.1001/jama.2016.17441. [PubMed: 27930760].
  • 2. Haerinejad MJ, Ostovar A, Farzaneh MR, Keshavarz M. The prevalence and characteristics of performance enhancing drug use among bodybuilding athletes in the south of Iran, Bushehr. Asian J Sports Med. 2016;7(3):35018. doi: 10.5812/asjsm.35018. [PubMed: 27826400].
  • 3. De Francesco Daher E, Mesquita Martiniano LV, Lopes Lima LL, Viana Leite Filho NC, de Oliveira Souza LE, Duarte Fernandes PH, et al. Acute kidney injury due to excessive and prolonged intramuscular injection of veterinary supplements containing vitamins A, D and E, A series of 16 cases. Nefrologia. 2017;37(1):61-7. doi: 10.1016/j.nefro.2016.05.017. [PubMed: 27577045].
  • 4. Abrahin OS, Sousa EC, Santos AM. Prevalence of the use of anabolic-androgenic steroids in Brazil: a systematic review. Subst Use Misuse. 2014;49(9):1156-62. doi: 10.3109/10826084.2014.903750. [PubMed: 24766401].
  • 5. Saragiotto BT, Di Pierro C, Lopes AD. Risk factors and injury prevention in elite athletes: a descriptive study of the opinions of physical therapists, doctors and trainers. Braz J Phys Ther. 2014;18(2):137-43. [PubMed: 24845023].
  • 6. Verhagen EA, van Stralen MM, van Mechelen W. Behaviour, the key factor for sports injury prevention. Sports Med. 2010;40(11):899-906. doi: 10.2165/11536890-000000000-00000. [PubMed: 20942507].
  • 7. Hawkins MS, Sevick MA, Richardson CR, Fried LF, Arena VC, Kriska AM. Association between physical activity and kidney function: National Health and Nutrition Examination Survey. Med Sci Sports Exerc. 2011;43(8):1457-64. doi: 10.1249/MSS.0b013e31820c0130. [PubMed: 21200336].
  • 8. Daher EF, Silva Junior GB, Queiroz AL, Ramos LM, Santos SQ, Barreto DM, et al. Acute kidney injury due to anabolic steroid and vitamin supplement abuse: report of two cases and a literature review. Int Urol Nephrol. 2009;41(3):717-23. doi: 10.1007/s11255-009-9571-8. [PubMed: 19387860].
  • 9. Wu I, Parikh CR. Screening for kidney diseases: older measures versus novel biomarkers. Clin J Am Soc Nephrol. 2008;3(6):1895-901. doi: 10.2215/CJN.02030408. [PubMed: 18922990].
  • 10. Mischak H, Delles C, Vlahou A, Vanholder R. Proteomic biomarkers in kidney disease: issues in development and implementation. Nat Rev Nephrol. 2015;11(4):221-32. doi: 10.1038/nrneph.2014.247. [PubMed: 25643662].
  • 11. Klein J, Bascands JL, Mischak H, Schanstra JP. The role of urinary peptidomics in kidney disease research. Kidney Int. 2016;89(3):539-45. doi: 10.1016/j.kint.2015.10.010. [PubMed: 26880450].
  • 12. Levey AS, Stevens LA, Schmid CH, Zhang YL, Castro A3, Feldman HI, et al. A new equation to estimate glomerular filtration rate. Ann Intern Med. 2009;150(9):604-12. [PubMed: 19414839].
  • 13. Borg GA. Psychophysical bases of perceived exertion. Med Sci Sports Exerc. 1982;14(5):377-81. [PubMed: 7154893].
  • 14. Joy JM, Lowery RP, Falcone PH, Vogel RM, Mosman MM, Tai CY, et al. A multi-ingredient, pre-workout supplement is apparently safe in healthy males and females. Food Nutr Res. 2015;59:27470. doi: 10.3402/fnr.v59.27470. [PubMed: 26085481].
  • 15. Macedo CLD, Santos RP, Pasqualoto AC, Copette FR, Pereira SM, Casagrande A, et al. The use of anabolic androgenic steroids by weight lifters and physical fitness athletes. Rev Bras Med Esporte. 1998;4(1):12-29. doi: 10.1590/s1517-86921998000100004.
  • 16. Frizon F, Macedo SMD, Yonamine M. Use of anabolic androgenic steroids by sports practitioners attending the main gym centers in erechim and passo fundo (Brazil). Rev Cienc Farm Basica Apl. 2005;26(3):227-32.
  • 17. Nogueira FRD, Brito ADF, Vieira TI, Oliveira CVC, Gouveia RLB. Prevalence of use of ergogenic aids among strength training apprentices in Joao pessoa. Rev Bras Cienc Esporte. 2015;37(1):56-64. doi: 10.1016/j.rbce.2013.12.001.
  • 18. Tebas BA, Silva MG, Gontijo EEL. Evaluation of the use of anabolic in academies of gurupi, tocantins. Rev Movimenta. 2012;5(3):209-16.
  • 19. Gheshlaghi F, Piri-Ardakani MR, Masoumi GR, Behjati M, Paydar P. Cardiovascular manifestations of anabolic steroids in association with demographic variables in body building athletes. J Res Med Sci. 2015;20(2):165-8. [PubMed: 25983770].
  • 20. Luchi WM, Ricarte RN, Roitman LF, Santos Oda R. [Nephrocalcinosis associated with the use of anabolic steroid]. J Bras Nefrol. 2015;37(1):135-40. doi: 10.5935/0101-2800.20150020. [PubMed: 25923762].
  • 21. Winnett G, Cranfield L, Almond M. Apparent renal disease due to elevated creatinine levels associated with the use of boldenone. Nephrol Dial Transplant. 2011;26(2):744-7. doi: 10.1093/ndt/gfq663. [PubMed: 20980358].
  • 22. Brou NA, Jacqz-Aigrain E, Zhao W. Cystatin C as a potential biomarker for dosing of renally excreted drugs. Br J Clin Pharmacol. 2015;80(1):20-7. doi: 10.1111/bcp.12602. [PubMed: 25655191].
  • 23. Frankenfeld SP, Oliveira LP, Ortenzi VH, Rego Monteiro IC, Chaves EA, Ferreira AC, et al. The anabolic androgenic steroid nandrolone decanoate disrupts redox homeostasis in liver, heart and kidney of male Wistar rats. PLoS One. 2014;9(9):102699. doi: 10.1371/journal.pone.0102699. [PubMed: 25225984].

Featured Image:

Creative Commons License Except where otherwise noted, this work is licensed under Creative Commons Attribution Non Commercial 4.0 International License .

Search Relations:



Create Citiation Alert
via Google Reader

Readers' Comments