Asian Journal of Sports Medicine

Published by: Kowsar

Cognitive Function and Dynamic Cerebral Blood Flow Regulation in Multiple Concussions

Akira Kumazaki 1 , * , Shigehiko Ogoh 2 , Ai Hirasawa 2 , Sadayoshi Sakai 3 and Norikazu Hirose 4
Authors Information
1 Department of Health and Sports, Faculty of Health Sciences, Niigata University of Health and Welfare, Japan
2 Department of Biomedical Engineering, Toyo University, Japan
3 Department of Orthopaedic Sports Medicine, Graduate School of Sport Sciences, Waseda University, Japan
4 Faculty of Sport Sciences, Waseda University, Japan
Article information
  • Asian Journal of Sports Medicine: March 2018, 9 (1); e67660
  • Published Online: March 10, 2018
  • Article Type: Research Article
  • Received: January 17, 2017
  • Accepted: August 21, 2017
  • DOI: 10.5812/asjsm.67660

To Cite: Kumazaki A, Ogoh S, Hirasawa A, Sakai S, Hirose N. Cognitive Function and Dynamic Cerebral Blood Flow Regulation in Multiple Concussions, Asian J Sports Med. 2018 ; 9(1):e67660. doi: 10.5812/asjsm.67660.

Copyright © 2018, Asian Journal of Sports Medicine. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited
1. Background
2. Objectives
3. Methods
4. Results
5. Discussion
  • 1. Gardner AJ, Iverson GL, Williams WH, Baker S, Stanwell P. A systematic review and meta-analysis of concussion in rugby union. Sports Med. 2014;44(12):1717-31. doi: 10.1007/s40279-014-0233-3. [PubMed: 25138311].
  • 2. Castile L, Collins CL, McIlvain NM, Comstock RD. The epidemiology of new versus recurrent sports concussions among high school athletes, 2005-2010. Br J Sports Med. 2012;46(8):603-10. doi: 10.1136/bjsports-2011-090115. [PubMed: 22144000].
  • 3. McCrory P, Meeuwisse W, Johnston K, Dvorak J, Aubry M, Molloy M, et al. Consensus Statement on Concussion in Sport: the 3rd International Conference on Concussion in Sport held in Zurich, November 2008. Br J Sports Med. 2009;43 Suppl 1:i76-90. doi: 10.1136/bjsm.2009.058248. [PubMed: 19433429].
  • 4. McCrory P, Meeuwisse WH, Aubry M, Cantu B, Dvorak J, Echemendia RJ, et al. Consensus statement on concussion in sport: the 4th International Conference on Concussion in Sport held in Zurich, November 2012. Br J Sports Med. 2013;47(5):250-8. doi: 10.1136/bjsports-2013-092313. [PubMed: 23479479].
  • 5. McClincy MP, Lovell MR, Pardini J, Collins MW, Spore MK. Recovery from sports concussion in high school and collegiate athletes. Brain Inj. 2006;20(1):33-9. doi: 10.1080/02699050500309817. [PubMed: 16403698].
  • 6. Giza CC, Hovda DA. The Neurometabolic Cascade of Concussion. J Athl Train. 2001;36(3):228-35. [PubMed: 12937489].
  • 7. Ahman S, Saveman BI, Styrke J, Bjornstig U, Stalnacke BM. Long-term follow-up of patients with mild traumatic brain injury: a mixed-method study. J Rehabil Med. 2013;45(8):758-64. doi: 10.2340/16501977-1182. [PubMed: 24002311].
  • 8. Bailey DM, Jones DW, Sinnott A, Brugniaux JV, New KJ, Hodson D, et al. Impaired cerebral haemodynamic function associated with chronic traumatic brain injury in professional boxers. Clin Sci (Lond). 2013;124(3):177-89. doi: 10.1042/CS20120259. [PubMed: 22913765].
  • 9. Metting Z, Spikman JM, Rodiger LA, van der Naalt J. Cerebral perfusion and neuropsychological follow up in mild traumatic brain injury: acute versus chronic disturbances?. Brain Cogn. 2014;86:24-31. doi: 10.1016/j.bandc.2014.01.012. [PubMed: 24556319].
  • 10. Hart JJ, Kraut MA, Womack KB, Strain J, Didehbani N, Bartz E, et al. Neuroimaging of cognitive dysfunction and depression in aging retired National Football League players: a cross-sectional study. JAMA Neurol. 2013;70(3):326-35. doi: 10.1001/2013.jamaneurol.340. [PubMed: 23303193].
  • 11. Raftery M. Concussion and chronic traumatic encephalopathy: International Rugby Board's response. Br J Sports Med. 2014;48(2):79-80. doi: 10.1136/bjsports-2013-093051. [PubMed: 24096899].
  • 12. Chen JK, Johnston KM, Frey S, Petrides M, Worsley K, Ptito A. Functional abnormalities in symptomatic concussed athletes: an fMRI study. Neuroimage. 2004;22(1):68-82. doi: 10.1016/j.neuroimage.2003.12.032. [PubMed: 15109998].
  • 13. McAllister TW, Sparling MB, Flashman LA, Guerin SJ, Mamourian AC, Saykin AJ. Differential working memory load effects after mild traumatic brain injury. Neuroimage. 2001;14(5):1004-12. doi: 10.1006/nimg.2001.0899. [PubMed: 11697932].
  • 14. Meier TB, Bellgowan PS, Singh R, Kuplicki R, Polanski DW, Mayer AR. Recovery of cerebral blood flow following sports-related concussion. JAMA Neurol. 2015;72(5):530-8. doi: 10.1001/jamaneurol.2014.4778. [PubMed: 25730545].
  • 15. Giza CC, Hovda DA. The new neurometabolic cascade of concussion. Neurosurgery. 2014;75 Suppl 4:S24-33. doi: 10.1227/NEU.0000000000000505. [PubMed: 25232881].
  • 16. MacFarlane MP, Glenn TC. Neurochemical cascade of concussion. Brain Inj. 2015;29(2):139-53. doi: 10.3109/02699052.2014.965208. [PubMed: 25587743].
  • 17. Junger EC, Newell DW, Grant GA, Avellino AM, Ghatan S, Douville CM, et al. Cerebral autoregulation following minor head injury. J Neurosurg. 1997;86(3):425-32. doi: 10.3171/jns.1997.86.3.0425. [PubMed: 9046298].
  • 18. Rangel-Castilla L, Gasco J, Nauta HJ, Okonkwo DO, Robertson CS. Cerebral pressure autoregulation in traumatic brain injury. Neurosurg Focus. 2008;25(4):7. doi: 10.3171/FOC.2008.25.10.E7. [PubMed: 18828705].
  • 19. Collie A, Maruff P, Makdissi M, McCrory P, McStephen M, Darby D. CogSport: reliability and correlation with conventional cognitive tests used in postconcussion medical evaluations. Clin J Sport Med. 2003;13(1):28-32. [PubMed: 12544161].
  • 20. Collie A, Makdissi M, Maruff P, Bennell K, McCrory P. Cognition in the days following concussion: comparison of symptomatic versus asymptomatic athletes. J Neurol Neurosurg Psychiatry. 2006;77(2):241-5. doi: 10.1136/jnnp.2005.073155. [PubMed: 16421129].
  • 21. Makdissi M, Darby D, Maruff P, Ugoni A, Brukner P, McCrory PR. Natural history of concussion in sport: markers of severity and implications for management. Am J Sports Med. 2010;38(3):464-71. doi: 10.1177/0363546509349491. [PubMed: 20194953].
  • 22. Ogoh S, Brothers RM, Eubank WL, Raven PB. Autonomic neural control of the cerebral vasculature: acute hypotension. Stroke. 2008;39(7):1979-87. doi: 10.1161/STROKEAHA.107.510008. [PubMed: 18451346].
  • 23. Iverson GL, Gaetz M, Lovell MR, Collins MW. Cumulative effects of concussion in amateur athletes. Brain Inj. 2004;18(5):433-43. doi: 10.1080/02699050310001617352. [PubMed: 15195792].
  • 24. McAllister TW, Flashman LA, Maerlender A, Greenwald RM, Beckwith JG, Tosteson TD, et al. Cognitive effects of one season of head impacts in a cohort of collegiate contact sport athletes. Neurology. 2012;78(22):1777-84. doi: 10.1212/WNL.0b013e3182582fe7. [PubMed: 22592370].
  • 25. Tator CH, Davis H. The postconcussion syndrome in sports and recreation: clinical features and demography in 138 athletes. Neurosurgery. 2014;75 Suppl 4:S106-12. doi: 10.1227/NEU.0000000000000484. [PubMed: 25232874].
  • 26. Dean PJ, Sato JR, Vieira G, McNamara A, Sterr A. Multimodal imaging of mild traumatic brain injury and persistent postconcussion syndrome. Brain Behav. 2015;5(1):45-61. doi: 10.1002/brb3.292. [PubMed: 25722949].
  • 27. Erlanger DM. Exposure to sub-concussive head injury in boxing and other sports. Brain Inj. 2015;29(2):171-4. doi: 10.3109/02699052.2014.965211. [PubMed: 25313457].

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