Asian Journal of Sports Medicine

Published by: Kowsar

Comparison of the Effects of Two Different Intensities of Combined Training on Irisin, Betatrophin, and Insulin Levels in Women with Type 2 Diabetes

Mahtab Enteshary 1 , Fahimeh Esfarjani 1 , * and Jalil Reisi 1
Authors Information
1 Exercise Physiology Department, University of Isfahan, Isfahan, Iran
Article information
  • Asian Journal of Sports Medicine: 10 (2); e68943
  • Published Online: June 9, 2019
  • Article Type: Research Article
  • Received: March 27, 2018
  • Revised: March 18, 2019
  • Accepted: March 31, 2019
  • DOI: 10.5812/asjsm.68943

To Cite: Enteshary M, Esfarjani F, Reisi J. Comparison of the Effects of Two Different Intensities of Combined Training on Irisin, Betatrophin, and Insulin Levels in Women with Type 2 Diabetes, Asian J Sports Med. Online ahead of Print ; 10(2):e68943. doi: 10.5812/asjsm.68943.

Copyright © 2019, Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Methods
4. Results
5. Discussion
  • 1. O'Brien JA, Shomphe LA, Kavanagh PL, Raggio G, Caro JJ. Direct medical costs of complications resulting from type 2 diabetes in the U.S. Diabetes Care. 1998;21(7):1122-8. doi: 10.2337/diacare.21.7.1122. [PubMed: 9653606].
  • 2. Eves ND, Plotnikoff RC. Resistance training and type 2 diabetes: Considerations for implementation at the population level. Diabetes Care. 2006;29(8):1933-41. doi: 10.2337/dc05-1981. [PubMed: 16873809].
  • 3. Pesta DH, Goncalves RLS, Madiraju AK, Strasser B, Sparks LM. Resistance training to improve type 2 diabetes: Working toward a prescription for the future. Nutr Metab (Lond). 2017;14:24. doi: 10.1186/s12986-017-0173-7. [PubMed: 28270856]. [PubMed Central: PMC5335813].
  • 4. [No authors listed]. Report of the expert committee on the diagnosis and classification of diabetes mellitus. Diabetes Care. 1997;20(7):1183-97. doi: 10.2337/diacare.20.7.1183. [PubMed: 9203460].
  • 5. Kurdiova T, Balaz M, Vician M, Maderova D, Vlcek M, Valkovic L, et al. Effects of obesity, diabetes and exercise on Fndc5 gene expression and irisin release in human skeletal muscle and adipose tissue: In vivo and in vitro studies. J Physiol. 2014;592(5):1091-107. doi: 10.1113/jphysiol.2013.264655. [PubMed: 24297848]. [PubMed Central: PMC3948565].
  • 6. Abu-Farha M, Al Madhoun A, Abubaker J. The rise and the fall of betatrophin/ANGPTL8 as an inducer of beta-cell proliferation. J Diabetes Res. 2016;2016:4860595. doi: 10.1155/2016/4860595. [PubMed: 27672665]. [PubMed Central: PMC5031879].
  • 7. Fu Z, Berhane F, Fite A, Seyoum B, Abou-Samra AB, Zhang R. Elevated circulating lipasin/betatrophin in human type 2 diabetes and obesity. Sci Rep. 2014;4:5013. doi: 10.1038/srep05013. [PubMed: 24852694]. [PubMed Central: PMC5381405].
  • 8. Huh JY, Panagiotou G, Mougios V, Brinkoetter M, Vamvini MT, Schneider BE, et al. FNDC5 and irisin in humans: I. Predictors of circulating concentrations in serum and plasma and II. mRNA expression and circulating concentrations in response to weight loss and exercise. Metabolism. 2012;61(12):1725-38. doi: 10.1016/j.metabol.2012.09.002. [PubMed: 23018146]. [PubMed Central: PMC3614417].
  • 9. Sanchis-Gomar F, Perez-Quilis C. The p38-PGC-1alpha-irisin-betatrophin axis: Exploring new pathways in insulin resistance. Adipocyte. 2014;3(1):67-8. doi: 10.4161/adip.27370. [PubMed: 24575373]. [PubMed Central: PMC3917937].
  • 10. Robergs RA, Roberts S. Fundamental principles of exercise physiology: For fitness, performance, and health. McGraw-Hill College; 2000.
  • 11. American Diabetes Association. Diagnosis and classification of diabetes mellitus. Diabetes Care. 2010;33 Suppl 1:S62-9. doi: 10.2337/dc10-S062. [PubMed: 20042775]. [PubMed Central: PMC2797383].
  • 12. Alberti KG, Zimmet PZ. Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus provisional report of a WHO consultation. Diabet Med. 1998;15(7):539-53. doi: 10.1002/(SICI)1096-9136(199807)15:7<539::AID-DIA668>3.0.CO;2-S. [PubMed: 9686693].
  • 13. McGarrah RW, Slentz CA, Kraus WE. The effect of vigorous- versus moderate-intensity aerobic exercise on insulin action. Curr Cardiol Rep. 2016;18(12):117. doi: 10.1007/s11886-016-0797-7. [PubMed: 27796854].
  • 14. Hordern MD, Dunstan DW, Prins JB, Baker MK, Singh MA, Coombes JS. Exercise prescription for patients with type 2 diabetes and pre-diabetes: A position statement from Exercise and Sport Science Australia. J Sci Med Sport. 2012;15(1):25-31. doi: 10.1016/j.jsams.2011.04.005. [PubMed: 21621458].
  • 15. Page P, Ellenbecker TS. The scientific and clinical application of elastic resistance. Human Kinetics; 2003.
  • 16. Bostrom P, Wu J, Jedrychowski MP, Korde A, Ye L, Lo JC, et al. A PGC1-alpha-dependent myokine that drives brown-fat-like development of white fat and thermogenesis. Nature. 2012;481(7382):463-8. doi: 10.1038/nature10777. [PubMed: 22237023]. [PubMed Central: PMC3522098].
  • 17. Norheim F, Langleite TM, Hjorth M, Holen T, Kielland A, Stadheim HK, et al. The effects of acute and chronic exercise on PGC-1alpha, irisin and browning of subcutaneous adipose tissue in humans. FEBS J. 2014;281(3):739-49. doi: 10.1111/febs.12619. [PubMed: 24237962].
  • 18. Loffler D, Muller U, Scheuermann K, Friebe D, Gesing J, Bielitz J, et al. Serum irisin levels are regulated by acute strenuous exercise. J Clin Endocrinol Metab. 2015;100(4):1289-99. doi: 10.1210/jc.2014-2932. [PubMed: 25625801].
  • 19. Tsuchiya Y, Ando D, Goto K, Kiuchi M, Yamakita M, Koyama K. High-intensity exercise causes greater irisin response compared with low-intensity exercise under similar energy consumption. Tohoku J Exp Med. 2014;233(2):135-40. doi: 10.1620/tjem.233.135. [PubMed: 24910199].
  • 20. Pekkala S, Wiklund PK, Hulmi JJ, Ahtiainen JP, Horttanainen M, Pollanen E, et al. Are skeletal muscle FNDC5 gene expression and irisin release regulated by exercise and related to health? J Physiol. 2013;591(21):5393-400. doi: 10.1113/jphysiol.2013.263707. [PubMed: 24000180]. [PubMed Central: PMC3936375].
  • 21. Hakimi M, Hosseini SA. [The changes of irisin serum levels and lipid profile of overweight male students after eight weeks of aerobic training]. J Shahid Sadoughi Univ Med Sci. 2016;23(12):1233-45. Persian.
  • 22. Yi P, Park JS, Melton DA. Betatrophin: A hormone that controls pancreatic beta cell proliferation. Cell. 2013;153(4):747-58. doi: 10.1016/j.cell.2013.04.008. [PubMed: 23623304]. [PubMed Central: PMC3756510].
  • 23. Chen CC, Susanto H, Chuang WH, Liu TY, Wang CH. Higher serum betatrophin level in type 2 diabetes subjects is associated with urinary albumin excretion and renal function. Cardiovasc Diabetol. 2016;15:3. doi: 10.1186/s12933-015-0326-9. [PubMed: 26739836]. [PubMed Central: PMC4704426].
  • 24. Xie X, Gao T, Yang M, Chen P, Jin H, Yang L, et al. Associations of betatrophin levels with irisin in Chinese women with normal glucose tolerance. Diabetol Metab Syndr. 2015;7:26. doi: 10.1186/s13098-015-0019-2. [PubMed: 25859278]. [PubMed Central: PMC4391688].
  • 25. Zheng C, Liu Z. Vascular function, insulin action, and exercise: An intricate interplay. Trends Endocrinol Metab. 2015;26(6):297-304. doi: 10.1016/j.tem.2015.02.002. [PubMed: 25735473]. [PubMed Central: PMC4450131].
  • 26. Kadoglou NP, Iliadis F, Liapis CD, Perrea D, Angelopoulou N, Alevizos M. Beneficial effects of combined treatment with rosiglitazone and exercise on cardiovascular risk factors in patients with type 2 diabetes. Diabetes Care. 2007;30(9):2242-4. doi: 10.2337/dc07-0341. [PubMed: 17586747].
  • 27. Rawal LB, Tapp RJ, Williams ED, Chan C, Yasin S, Oldenburg B. Prevention of type 2 diabetes and its complications in developing countries: a review. Int J Behav Med. 2012;19(2):121-33. doi: 10.1007/s12529-011-9162-9. [PubMed: 21590464]. [PubMed Central: PMC3358560].

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